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1

Discovery and development of antiviral drugs for biodefense: Experience of a small biotechnology company

Tove C. Bolken, Dennis E. Hruby

Journal:

Antiviral Research

Year:

2008

Language:

english

File:

PDF, 197 KB

english, 2008

2

The values and visions of the professional department head: not so different from the past?

Møthe, Svein, Ballangrud, Brit Olaug Bolken, Stensaker, Bjørn

Journal:

International Journal of Educational Management

Year:

2015

Language:

english

File:

PDF, 170 KB

english, 2015

3

Identification of an intragenic integration site for foreign gene expression in recombinantStreptococcus gordoniistrains

Tove C. Bolken, Christine A. Franke, Gloria O. Zeller, Dennis E. Hruby

Journal:

Applied Microbiology and Biotechnology

Year:

2001

Language:

english

File:

PDF, 108 KB

english, 2001

4

Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses

Tove′ C. Bolken, Sylvie Laquerre, Yuanming Zhang, Thomas R. Bailey, Daniel C. Pevear, Shirley S. Kickner, Lindsey E. Sperzel, Kevin F. Jones, Travis K. Warren, S. Amanda Lund, Dana L. Kirkwood-Watts,

Journal:

Antiviral Research

Year:

2006

Language:

english

File:

PDF, 485 KB

english, 2006

5

Successful Treatment in the Monkeypox and Variola Primate Models of Smallpox by the Oral Drug ST-246

John Huggins, Arthur Goff, Mucker Eric, Nancy Twenhafel, Jennifer Chapman, Mallory Tate, Rob Jordan, Tove’ Bolken, Dennis Hruby

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 65 KB

english, 2007

6

Single-Dose Safety and Pharmacokinetics of ST-246, A Novel Orthopoxvirus Egress Inhibitor

Robert Jordan, Kevin Jones, Tove’ Bolken, Deborah Tien, Josef Strasser, T.R. Shanthakumar, Annie Frimm, Michael Corrado, Phoebe Strome, Dennis Hruby

Journal:

Antiviral Research

Year:

2008

Language:

english

File:

PDF, 65 KB

english, 2008

7

Evaluation of Lassa antiviral compound ST-193 in a guinea pig model

Kathleen A. Cashman, Mark A. Smith, Nancy A. Twenhafel, Ryan A. Larson, Kevin F. Jones, Robert D. Allen III, Dongcheng Dai, Jarasvech Chinsangaram, Tove’ C. Bolken, Dennis E. Hruby, Sean M. Amberg, Li

Journal:

Antiviral Research

Year:

2011

Language:

english

File:

PDF, 1.66 MB

english, 2011

8

Expression and Purification of Histidine-Tagged Proteins from the Gram-Positive Streptococcus gordonii SPEX System

Dawn M. Myscofski, Emma K. Dutton, Tové C. Bolken, Christine A. Franke, Dennis E. Hruby

Journal:

Protein Expression and Purification

Year:

2000

Language:

english

File:

PDF, 170 KB

english, 2000

9

Expression of Active Monomeric and Dimeric Nuclease A from the Gram-Positive Streptococcus gordonii Surface Protein Expression System

Emma K. Dutton, Sean A. Ottum, Tove′ C. Bolken, Christine A. Franke, Dennis E. Hruby

Journal:

Protein Expression and Purification

Year:

2000

Language:

english

File:

PDF, 384 KB

english, 2000

10

Biological consequences of antigen and cytokine co-expression by recombinant Streptococcus gordonii vaccine vectors

Chelsea M. Byrd, Tove’ C. Bolken, Kevin F. Jones, Travis K. Warren, Anthony T. Vella, Jenny McDonald, David King, Zach Blackwood, Dennis E. Hruby

Journal:

Year:

2002

Language:

english

File:

PDF, 444 KB

english, 2002

11

Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole

Dai, Dongcheng, Burgeson, James R., Gharaibeh, Dima N., Moore, Amy L., Larson, Ryan A., Cerruti, Natasha R., Amberg, Sean M., Bolken, Tove’ C., Hruby, Dennis E.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.33 MB

english, 2013

12

Lead optimization of an acylhydrazone scaffold possessing antiviral activity against Lassa virus

Burgeson, James R., Gharaibeh, Dima N., Moore, Amy L., Larson, Ryan A., Amberg, Sean M., Bolken, Tove’ C., Hruby, Dennis E., Dai, Dongcheng

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.47 MB

english, 2013

13

Ascorbic acid regeneration by bovine iris-ciliary body

Bode, Ann M., Green, Edie, Yavarow, Christy R., Wheeldon, Susan L., Bolken, Stephanie, Gomez, Yvonne, Rose, Richard C.

Journal:

Current Eye Research

Year:

1993

Language:

english

File:

PDF, 772 KB

english, 1993

14

Nonhuman Primates Are Protected from Smallpox Virus or Monkeypox Virus Challenges by the Antiviral Drug ST-246

Huggins, J., Goff, A., Hensley, L., Mucker, E., Shamblin, J., Wlazlowski, C., Johnson, W., Chapman, J., Larsen, T., Twenhafel, N., Karem, K., Damon, I. K., Byrd, C. M., Bolken, T. C., Jordan, R., Hrub

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2009

Language:

english

File:

PDF, 920 KB

english, 2009

15

Pharmacokinetic Comparison of a Single Oral Dose of Polymorph Form I versus Form V Capsules of the Antiorthopoxvirus Compound ST-246 in Human Volunteers

Chinsangaram, J., Honeychurch, K. M., Tyavanagimatt, S. R., Bolken, T. C., Jordan, R., Jones, K. F., Marbury, T., Lichtenstein, I., Pickens, M., Corrado, M., Landis, P., Clarke, J. M., Frimm, A. M., H

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2012

Language:

english

File:

PDF, 313 KB

english, 2012

16

Safety and Pharmacokinetics of the Anti-Orthopoxvirus Compound ST-246 following a Single Daily Oral Dose for 14 Days in Human Volunteers

Chinsangaram, J., Honeychurch, K. M., Tyavanagimatt, S. R., Leeds, J. M., Bolken, T. C., Jones, K. F., Jordan, R., Marbury, T., Ruckle, J., Mee-Lee, D., Ross, E., Lichtenstein, I., Pickens, M., Corrad

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2012

Language:

english

File:

PDF, 277 KB

english, 2012

17

Safety and Pharmacokinetics of the Antiorthopoxvirus Compound ST-246 following Repeat Oral Dosing in Healthy Adult Subjects

Jordan, R., Chinsangaram, J., Bolken, T. C., Tyavanagimatt, S. R., Tien, D., Jones, K. F., Frimm, A., Corrado, M. L., Pickens, M., Landis, P., Clarke, J., Marbury, T. C., Hruby, D. E.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2010

Language:

english

File:

PDF, 391 KB

english, 2010

18

Analysis of Factors Affecting Surface Expression and Immunogenicity of Recombinant Proteins Expressed by Gram-Positive Commensal Vectors

Journal:

Infection and Immunity

Year:

2002

Language:

english

File:

PDF, 137 KB

english, 2002

19

Appendix 4: Standing Orders of the International Labour Conference as Adopted at the Twenty-Seventh Session on 22 October 1945

Grosenbach, D. W., Berhanu, A., King, D. S., Mosier, S., Jones, K. F., Jordan, R. A., Bolken, T. C., Hruby, D. E.

Journal:

The American Journal of International Law

Year:

1947

Language:

english

File:

PDF, 410 KB

english, 1947

20

Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice

Grosenbach, D. W., Berhanu, A., King, D. S., Mosier, S., Jones, K. F., Jordan, R. A., Bolken, T. C., Hruby, D. E.

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 364 KB

english, 2010

21

Identification of a Broad-Spectrum Arenavirus Entry Inhibitor

Larson, R. A., Dai, D., Hosack, V. T., Tan, Y., Bolken, T. C., Hruby, D. E., Amberg, S. M.

Journal:

Journal of Virology

Year:

2008

Language:

english

File:

PDF, 1.34 MB

english, 2008

22

Molecular Dissection of the Vaccinia Virus I7L Core Protein Proteinase

Byrd, C. M., Bolken, T. C., Hruby, D. E.

Journal:

Journal of Virology

Year:

2003

Language:

english

File:

PDF, 917 KB

english, 2003

23

Inactivation of the srtA Gene in Streptococcus gordonii Inhibits Cell Wall Anchoring of Surface Proteins and Decreases In Vitro and In Vivo Adhesion

Bolken, T. C., Franke, C. A., Jones, K. F., Zeller, G. O., Jones, C. H., Dutton, E. K., Hruby, D. E.

Journal:

Infection and Immunity

Year:

2001

Language:

english

File:

PDF, 149 KB

english, 2001

24

ST-246 Antiviral Efficacy in a Nonhuman Primate Monkeypox Model: Determination of the Minimal Effective Dose and Human Dose Justification

Jordan, R., Goff, A., Frimm, A., Corrado, M. L., Hensley, L. E., Byrd, C. M., Mucker, E., Shamblin, J., Bolken, T. C., Wlazlowski, C., Johnson, W., Chapman, J., Twenhafel, N., Tyavanagimatt, S., Amant

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2009

Language:

english

File:

PDF, 652 KB

english, 2009

25

IX Latin American Symposium on Mathematical Logic, Bahía Blanca, 1992

Jones, C. H., Bolken, T. C., Jones, K. F., Zeller, G. O., Hruby, D. E.

Journal:

Journal of Symbolic Logic

Year:

1994

Language:

english

File:

PDF, 1.05 MB

english, 1994

26

Conserved DegP Protease in Gram-Positive Bacteria Is Essential for Thermal and Oxidative Tolerance and Full Virulence in Streptococcus pyogenes

Jones, C. H., Bolken, T. C., Jones, K. F., Zeller, G. O., Hruby, D. E.

Journal:

Infection and Immunity

Year:

2001

Language:

english

File:

PDF, 4.19 MB

english, 2001

27

The Vaccinia Virus I7L Gene Product Is The Core Protein Proteinase

Byrd, C. M., Bolken, T. C., Hruby, D. E.

Journal:

Journal of Virology

Year:

2002

Language:

english

File:

PDF, 409 KB

english, 2002

28

New Class of Orthopoxvirus Antiviral Drugs That Block Viral Maturation

Byrd, C. M., Bolken, T. C., Mjalli, A. M., Arimilli, M. N., Andrews, R. C., Rothlein, R., Andrea, T., Rao, M., Owens, K. L., Hruby, D. E.

Journal:

Journal of Virology

Year:

2004

Language:

english

File:

PDF, 743 KB

english, 2004

29

Single-Dose Safety and Pharmacokinetics of ST-246, a Novel Orthopoxvirus Egress Inhibitor

Jordan, R., Tien, D., Bolken, T. C., Jones, K. F., Tyavanagimatt, S. R., Strasser, J., Frimm, A., Corrado, M. L., Strome, P. G., Hruby, D. E.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2008

Language:

english

File:

PDF, 192 KB

english, 2008

30

Efficacy of ST-246 versus Lethal Poxvirus Challenge in Immunodeficient Mice

Douglas W. Grosenbach, Aklile Berhanu, David S. King, Stacie Mosier, Kevin F. Jones, Robert A. Jordan, Tove' C. Bolken, Dennis E. Hruby and Bernard Moss

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.29 MB

english, 2010

31

Pharmacokinetics and Interspecies Allometric Scaling of ST-246, an Oral Antiviral Therapeutic for Treatment of Orthopoxvirus Infection

Amantana, Adams, Chen, Yali, Tyavanagimatt, Shanthakumar R., Jones, Kevin F., Jordan, Robert, Chinsangaram, Jarasvech, Bolken, Tove′ C., Leeds, Janet M., Hruby, Dennis E., Mehta, Anand S.

Journal:

Year:

2013

Language:

english

File:

PDF, 428 KB

english, 2013